Federchimica

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Università degli Studi di Camerino, School of Pharmacy - Department of Chemistry Interdisciplinary Project (CHIP)

General Information

Università degli Studi di Camerino
School of Pharmacy - Department of Chemistry Interdisciplinary Project (CHIP)
Via Madonna delle carceri - 62032 Camerino (MC)
Web site: https://farmaco.unicam.it/
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Contacts
Prof. Gianni SAGRATINI
+39 0737402238

Detailed information

Staff
14 Full Professors
28 Associate Professors
13 Researchers
11 Structured Technicians
4 Administrative Technicians
 
Registered students
1,600 (Academic year 2023/2024)
Post Lauream Training
73 enrolled in doctoral programs in Chemical and Pharmaceutical Sciences and Biotechnology: Pharmaceutical, Nutraceutical and Food Sciences
57 enrolled in II level Master in Manager of Pharmaceutical Departments
24  enrolled in II level Master in Aesthetic medicine and therapy
17 enrolled in II level Master in Complementary and integrated Therapies
13 enrolled in II level Master in Industrial Drug Regulation
53 enrolled in II level Master in  Galenic Preparations
206 enrolled in II level Master in Aesthetic Medicine and Therapeutics (Athens Class and Rome Class)
7 enrolled in  Advanced course Aesthetic Medicine Assistant
17 enrolled in Advanced course Molecular aspects of nutrition: from nutrigenomics to funcional nutrition
20 Research fellows
8 Fellows 
 
Patents
14

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PRODUCTS
PROCESSES
SERVICES
TECHNOLOGIES
PROPRIETARY SEARCH
THIRD PARTY RESEARCH

R&D activities detail

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Botany

Green extraction, functional components and industrial applications of botanicals and waste materials from the agro-food sector
Filippo Maggi (+39 0737404506)
filippo.maggi@unicam.it
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Neuroprotective agents

Synthesis of nucleosides and heterocycles as ligands of adenosine receptors and neuroprotective and antiparkinsonian agents
Rosaria Volpini (+39 0737402278)
rosaria.volpini@unicam.it
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Food analysis

Development and optimization of analytical methods for the quantification of bioactive compounds and/or contaminants in food
Giovanni Caprioli (+39 0737402312)
giovanni.caprioli@unicam.it
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Nutraceutics

Valorization of bioactive compounds obtained from agri-food wastes for the formulation of nutraceutical supplements and functional foods
Sauro Vittori (+39 0737402266)
sauro.vittori@unicam.it
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Food science

Food quality and safety for human health and development of new foods with functional properties through the optimization of the production process
Gianni Sagratini (+39 0737402238)
gianni.sagratini@unicam.it
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Antitumours

Synthesis and development of organometallic complexes based on ruthenium, osmium, rhodium, and iridium with anticancer properties
Riccardo Pettinari (+39 0737402338)
riccardo.pettinari@unicam.it
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Muscarinic receptors

Design, synthesis, and biological evaluation of new muscarinic receptor agonists/antagonists therapeutically useful for the treatment of peripheral and central nervous system diseases
Alessandro Piergentili (+39 0737402235)
alessandro.piergentili@unicam.it
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PROTAC

Design, synthesis, and biological evaluation of new PROTACs bearing properly modified selective alpha1-adrenergic receptor ligands, potentially useful for the treatment of prostate cancer
Wilma Quaglia (+39 0737402237)
wilma.quaglia@unicam.it
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Antitumours

Synthesis and biological evaluation of new compounds interacting with nucleic acids as new potential antitumor drugs
Gabriella Marucci (+39 0737402223)
gabriella.marucci@unicam.it
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Dopamine receptors

Design, synthesis, and biological evaluation of novel agonists/antagonists selectively targeting dopamine receptor subtypes and potentially useful as novel pharmacological tools for the treatment of glioblastoma
Fabio Del Bello (+39 0737402265)
fabio.delbello@unicam.it
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Natural products

Rational design, synthesis, and characterization of new ligands with metal coordinating properties and extraction and purification of naturally occurring compounds from medicinal plants, for tackling Neglected Tropical Diseases (NTD)
Riccardo Petrelli (+39 0737402239)
riccardo.petrelli@unicam.it
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Smart polymers

Synthesis of new excipients and advanced formulations for pharmaceutical, biomedical and cosmetic applications
Roberta Censi (+39 0737402231)
roberta.censi@unicam.it
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Surfactants

Synthesis, chemical-physical characterization and toxicological evaluation of biodegradable amphiphilic molecules to be used as conventional surfactants and for the preparation of pharmaceutical carriers such as liposomes and mixed vesicles, micro and nano emulsions, micelles
Diego Romano Perinelli (+39 0737402289)
diego.perinelli@unicam.it
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DESs

Realization and characterization of new Deep Eutectic Solvents (DESs) as environmentally sustainable and environmentally friendly liquids
Matteo Tiecco (+39 0737402350)
matteo.tiecco@unicam.it
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Galenic

Study of the traditional galenic preparations set up into the pharmacy, applying the scientific approach of the pharmaceutical industry. Improvement of the traditional galenic preparations both from a formulative and a preparative point of view
Giovanni Filippo Palmieri (+39 0737402233)
gianfilippo.palmieri@unicam.it
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Enzymatic modulators

Synthesis and biological evaluation of heterocyclic compounds modulating enzymes with kinase activity as potential analgesics
Michela Buccioni (+39 0737402205)
michela.buccioni@unicam.it
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Anti-inflammatory agents

Synthesis of nucleotides and heterocycles as modulators of purinergic P2X receptors and anti-inflammatory agents
Catia Lambertucci (+39 0737402252)
catia.lambertucci@unicam.it
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Compounds

Evaluation of medicines manipulation (splitting, crushing, dispersing into a liquid or gel) identifying eventually risks related with specific features of the drug, the dosage form or excipients. Identification of alternative manipulation paths to match all the patient necessity
Giulia Bonacucina (+39 0737402289)
giulia.bonacucina@unicam.it
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Free radicals

Synthesis and study of new molecules that due to their chemical structure are capable of scavenging free radicals and due to this can have application in various formulations
Elisabetta Torregiani (+39 0737402249)
elisabetta.torregiani@unicam.it
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Metallic complexes

Synthesis and characterization of novel coordination compounds based on N-, O, and S-donor ligands biologically and pharmacologically active
Claudio Pettinari (+39 0737402234)
claudio.pettinari@unicam.it
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NanoRNA

Design, synthesis and characterization of dinucleotide-based compounds able to inhibit REXO2, an exoribonuclease overexpressed in many cancer cells
Loredana Cappellacci (+39 0737402228)
loredana.cappellacci@unicam.it
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MOF

Design and characterization of metal-organic frameworks (MOFs) for storage and conversion of gas and energy
Alessia Tombesi (+39 0737402234)
alessia.tombesi@unicam.it
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NMDA receptors

Design, synthesis, and biological evaluation of new noncompetitive NMDA receptor antagonists and sigma1 receptor ligands for the treatment of disorders in which they are involved
Gianfabio Giorgioni (+39 0737402368)
gianfabio.giorgioni@unicam.it
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Computational chemistry

Design of compounds as modulators of purinergic membrane receptors and enzymes with computational chemistry tools
Diego Dal Ben (+39 0737402236)
diego.dalben@unicam.it
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Tablets

Characterization of the functionality, mechanical and rheological properties of materials intended for solid oral dosage formulations. The materials are studied using instrumented rotary tablet machine, tensile tester, DMA, DSC and all standard procedures used for the solid oral dosage forms
Marco Cespi (+39 0737402285)
marco.cespi@unicam.it
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Sustainable recovery

Sustainable recovery of bioactive compounds and nutraceuticals from agri-food wastes sector
Cinzia Mannozzi (+39 0737402350)
cinzia.mannozzi@unicam.it
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Other R&D organizations

HPLC-MS and GC-MS Facilities
The mission of the HPLC-MS and GC-MS facilities is to provide centralized access to HPLC-MS and GC-MS resources for researchers at the University of Camerino
Contacts: Massimo Ricciutelli - massimo.ricciutelli@unicam.it
Web site: https://strumentazioni.unicam.it/laboratorio/laboratorio-hplc-ms
Nuclear Magnetic Resonance (NMR) Facility
The role of NMR Facility is to provide support for performing advanced NMR experiments
Contacts: Giovanni Rafaiani (+39 0737402208) - giovanni.rafaiani@unicam.it
Web site: https://strumentazioni.unicam.it/laboratorio/laboratorio-di-risonanza-magnetica-nucleare

Collaborations with companies

  • DFE Pharma
  • Evotec SE
  • Fileni S.p.A.
  • Indena S.p.A.
  • Janssen-Pharmaceutical S.p.A.
  • Nuova Simonelli S.p.A.
  • Puli Ecol Recuperi S.r.l.
  • Redantea S.r.l.
  • Sabelli S.p.A.
  • Società Agricola Borgo Paglianetto S.r.l.
  • Società Agricola Monte Monaco S.r.l.

Pubblicazioni

  • Perinelli, D.R.; Cespi, M.; Rendina, F.; Bonacucina, G.;  Palmieri, G.F., "Effect of the concentration process on unloaded and doxorubicin loaded liposomal dispersions",  International Journal of Pharmaceutics 2019, 560, 385–393.
  • Baldassarri, C.; Giorgioni, G.; Piergentili, A.; Quaglia, W.; Fontana, S.; Mammoli, V.; Minazzato, G.; Marangoni, E.; Gasparrini, M.; Sorci, L.;  Raffaelli, N.; Cappellacci, L.; Petrelli, R.; Del Bello, F., "Properly Substituted Benzimidazoles as a New Promising Class of Nicotinate Phosphoribosyltransferase (NAPRT) Modulators",  Pharmaceuticals, 2023, 16, 189
  • Alessandroni, L.; Caprioli, G.; Faiella, F.; Fiorini, D.; Galli, R.; Huang, X.; Marinelli, G.; Nzekoue, F.; Ricciutelli, M.; Scortichini, S.;  Silvi, S.; Tramontano, A.; Turati, D.; Sagratini, G., "A shelf-life study for the evaluation of a new biopackaging to preserve the quality of organic chicken meat", Food Chemistry, 2022, 371, 131134
  • Santanatoglia, A.; Caprioli, G.; Cespi, M.; Ciarlantini, D.; Cognigni, L.; Fioretti, L.; Maggi, F.; Mustafa, M.A.; Nzekoue, F.; Vittori, S., "A comprehensive comparative study among the newly developed Pure Brew method and classical ones for filter coffee production", LWT, 2023, 175, 114471
  • Del Bello, F.; Bonifazi, A.; Giorgioni, G.; Cifani, C.; Micioni Di Bonaventura, M.V.; Petrelli, R.; Piergentili, A.; Fontana, S.; Mammoli, V.; Yano, H.; Matucci, R.; Vistoli, G.; Quaglia, W., "1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a model for the rational design of a novel class of brain penetrant ligands with high affinity and selectivity for dopamine D4 receptor", J. Med. Chem. 2018, 61, 3712-25
  • Fagioli, L.; Pavoni, L.; Logrippo, S.; Pelucchini, C.; Rampoldi, L.; Cespi, M.; Bonacucina, G.; Casettari, L., "Linear viscoelastic properties of selected polysaccharide gums as function of concentration, pH, and temperature", Journal of Food Science 2019, 84, 65-72
  • Huang, X.; Nzekoue, F.K.; Renzi, S.; Alesi, A.; Coman, M.M.; Pucciarelli, S.; Sagratini, G.;  Silvi, S., "Influence of modified governing liquid on shelf-life parameters of high-moisture mozzarella cheese", Food Research International, 2022, 159, 111627