Chemical Research Handbook

Università di Pisa, Department of: Chemistry and Industrial chemistry

General Information

Università di Pisa
Department of: Chemistry and Industrial chemistry
Via Moruzzi 13 - 56124 Pisa (PI)
Web site: http://www.dcci.unipi.it
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Contacts
Prof. Fabio BELLINA
+39 0502219282

Detailed information

Staff
8 Full Professors
29 Associate Professors
27 Researchers
27 Structured Technicians
13 Administrative Technicians
2 General Services
Registered students
669 (Academic year 2022/2023)
Post Lauream Training
50 enrolled in Doctorates in Chemical Sciences
22 Research fellows
13 fellows
Patents
24
 

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PRODUCTS
PROCESSES
SERVICES
TECHNOLOGIES
PROPRIETARY SEARCH
THIRD PARTY RESEARCH

R&D activities detail

Organic synthesis

Development and application of synthetic methodologies to prepare novel chemical structures, through direct arylation reaction: evaluation of the C-H bonds reactivity of (hetero)arene systems in the direct arilation conditions and in the oxidative coupling conditions promote by metal catalysts or photoredox catalysts. Last Stage Functionalisation (LSF) of pharmaceutical interest (Hetero)arenes through C-H bond activation, in collaboration with Chiesi farmaeutici. Development of molecules for special application: synthesis of highly conjugated molecules, with distinctive optical properties, through novel highly efficient and economic approaches. Thanks to their properties those structures will be used in the area of solar and artificial light capture and transformation
Fabio Bellina (+39 0502219282)
fabio.bellina@unipi.it
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Heteroaromatic compounds

Study of new methods to create Carbon-Carbon bonds or Carbon-Heteroatom bonds, through reaction catalisied by transition metal o radical reactions. Use of classial batch protocols or mechanochemical approach. Synthesis of High conjugated (Hetero)Aromatic structures for technological application, capure of CO2 or harvest of light, and biological application, anti cancer activity
Marco Lessi (+39 0502219327)
marco.lessi@unipi.it
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Computational chemistry

Theoretical study of solvation processes. Calculation of energy surfaces and inter-molecular potentials. Classical and quantum simulations
Franca Maria Floris (+39 0502219393)
francamaria.floris@unipi.it
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Organic synthesis

Development of sustainable synthetic and catalytic methodologies for C-H bond functionalization. Development of electrochemical methodologies for application in organic synthesis and catalysis. Development of catalytic methodologies for oxidative/reductive and cross-electrophilic coupling reactions in presence of Earth-abundant transition-metals. Desing, synthesis and application of new ruthenium-based catalysts for olefinic metathesis. Developement of new methodologies for the 13C and 2H labeling of pharmaceuticals
Antonio Del Vecchio (+39 0502229275)
antonio.delvecchio@gmail.com
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Cultural heritage

Development of analytical methods based on analytical pyrolysis, mass spectrometry and chromatography or the analysis and quantification of microplastics in environmental samples. Development of new analytical methods for the characterisation and the study of the degradation of natural and synthetic organic materials, focusing on applications in heritage science
Jacopo La Nasa (+39 0502219309)
jacopo.lanasa@unipi.it
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Second skin

Preparation and characterization of nanocomposite poly(dimethyl siloxane)-based films with a complete UV-blocking action (funded by AIXP)
Elisa Martinelli (+39 0502219354)
elisa.martinelli@unipi.it
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Solventi eutettici

Preparation of new eutectics as innovative solvents, for the reversible absorption of CO2 and the chemical recycling of polymer waste items
Gianluca Ciancaleoni (+39 0502219351)
gianluca.ciancaleoni@unipi.it
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Reaction mechanisms

SPEC: spectroscopic analysis of complex systems for reaction mechanisms and speciation. Spectrophotometric, spectrofluorometric and fast kinetics (Stopped-flow, T-jump) approaches (together with electrophoresis and viscometry) are combined to get thermodynamic and kinetic information on complex systems (fluorophores/new materials; metal complexes; small molecules with biosubstrates; pollutants extraction from liquid wastes)
Tarita Biver (+39 0502219259)
tarita.biver@unipi.it
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Metal drugs

AIRC. "A multi-Omics approach to establish the molecular mechanisms of Anticancer Gold Compounds in the Systems Biology Era." This proposal is directed to develop new effective methodologies to determine the mechanism of action of six distinct gold compounds of large interest for medicinal chemistry that are promising experimental anticancer agents
Alessandro Pratesi (+39 0502219224)
alessandro.pratesi@unipi.it
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Porous materials

Development of novel solid adsorbents (metal-organic frameworks, solid amines) for gas separations, with focus on CO2 capture from post-combustion flue gas and directly from air
Marco Taddei (+39 0502219602)
marco.taddei@unipi.it
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Conjugated polymers

Developement of conjugated polymers for application in organic electronic devices and secondary metal-ion batteries

Drug delivery

Strategies development for the synthesis of bioactive molecules capable of selectively recognizing specific biomarkers. Development of smart materials for the production of drug delivery systems with controlled and "on-demand" release of active ingredient. Use of nuclear magnetic resonance (NMR) spectroscopy for the in-depth and complete study of the stereochemical, dynamic and thermodynamic characteristics of supramolecular aggregates involving from low to high molecular weight systems
Andrea Cesari (+39 0502219315)
andrea.cesari@unipi.it
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Deep Eutctic Solvents

Deep Eutctic Solvents: optimization of preparation by conventional heating or coaxial microwave antenna; study of density, viscosity, surface tension, thermal properties, etc., and evaluation of structure-properties relationship; study of applications in the field of extraction of high value-added components from biomass, electrodeposition, depolymerization
Chiara Pelosi (+39 0502219268)
chiara.pelosi@unipi.it
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Electrochemistry

Study of the redox processes of new organic, inorganic molecules and mononuclear or polynuclear organometallic transition metal complexes in water or in strictly anhydrous non aqueous solvents, under inert atmosphere. Spectroscopic characterization ( UV-vis, IR, EPR) of the relatively long-lived redox intermediates and study of the reactions of the metastable products thanks to "in situ" generation in spectroelectrochemical cells
Tiziana Funaioli (+39 0502219239)
tiziana.funaioli@unipi.it
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Biomimetics

Synthesis and conformational studies of biomimetics with biomedical activity, in particular towards the development of new antibiotics and antitumoral molecules
Gaetano Angelici (+39 0502219227)
gaetano.angelici@unipi.it
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Computational photochemistry

Computational photochemistry. Methodological development. Study of molecular switches and systems of interest in pharmacology and photovoltaics
Giovanni Granucci (+39 0502219238)
giovanni.granucci@unipi.it
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Functional polymers

PRIN2017: functional supramolecular polymers for self-diagnostic composites ERC Mama: functional polymers with mechanochromic features. PRIN2022: luminescent solar concentrators based on recycled poly(methyl methacrylate). ENEA project: preparation of ionomers and polymeric membranes with ionic-exchange features. ENI project: preparation of oil additives with dispersion and anti-friction characteristics
Andrea Pucci (+39 0502219270)
andrea.pucci@unipi.it
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Microplastics

Development of innovative protocols, based on chromatographic techniques coupled with mass spectrometry (GC-MS and LC-MS), for the quantitative analysis of microplastics in environmental matrices and their degradation or leaching products. Development of protocols for the characterization of the inflammatory response of cellular systems exposed to degraded microplastic material in order to assess their impact on cardiovascular diseases. Development and validation of analytical procedures, based on chromatographic techniques coupled with mass spectrometry (GC-MS and LC-MS), for monitoring the health status of individuals through the determination of biomarkers in biological fluids such as saliva, sweat, exhaled breath, nails, plasma, and blood.
Tommaso Lomonaco (+39 0502219248)
tommaso.lomonaco@unipi.it
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Composites

Preparation and characterization of multifunctional composites/nanocomposites based on biopolymers, natural fibers, wastes, inorganic fillers
Grazia Totaro (+39 0502219319)
grazia.totaro@unipi.it
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Nanomaterials

Design, preparation and characterization of nanosystems for optoelectronics, magnetism, nanomedicine and photovoltaics
Francesco Pineider (+39 0502219313)
francesco.pineider@unipi.it
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Chirality

Synthesis of chiral auxiliaries starting from renewable resources and their use in enantiodiscrimination : chiral ligands for asymmetric catalysis in the preparation of API, chiral auxiliaries for the determination of the enantiomeric composition of bioactive compounds
Anna Iuliano (+39 0502219232)
anna.iuliano@unipi.it
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Spectroscopy

Spectroscopy applied to the study of liquid crystals, LC elastomers, memory shaped materials. Spectroscopic methods applied to food and agricultural products.
Valentina Domenici (+39 0502219215)
valentina.domenici@unipi.it
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Transparent wood

Preparation of transparent wood from natural wood and wood waste (VEGETAS project, Regione Toscana and Camarlinghi SpA)
Elisa Martinelli (+39 0502219354)
elisa.martinelli@unipi.it
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Metal drugs

“ACTIVATABLE PT(IV) COMPOUNDS AS POTENTIAL ANTICANCER PRODRUGS AND NEW STRATEGIES TO OVERCOME LIMITS OF PLATINUM-BASED CHEMOTHERAPY IN COLORECTAL CANCER.” “The project aims to the synthesis of new Pt(IV) complexes endowed of bioactive axial ligands starting from the oxidation of the respective Pt(II) precursors. Once the syntheses are optimized, alternative Pt complexes will be considered with the purpose of finding compounds with greater bioactivity.
Chiara Gabbiani (+39 0502219225)
chiara.gabbiani@unipi.it
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SSNMR

Application of solid-state NMR spectroscopy to explore the structure and dynamics of porous materials for gas separation and adsorption
Francesca Martini (+39 0502219353)
francesca.martini@unipi.it
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Filler

Synthesis and characterization of inorganic fillers with specific functionalities
Grazia Totaro (+39 0502219319)
grazia.totaro@unipi.it
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Flow chemistry

Development of new methods exploiting continuous-flow reactors for selective organic transformations, either with homogeneous catalysis or with supported systems
Alessandro Mandoli (+39 0502219281)
alessandro.mandoli@unipi.it
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Analytical methods

Development of analytical methods based on liquid chromatography with DAD detection or mass spectrometric detection for the characterisation of organic dyes and pigments in complex matrices (e.g. heritage objecs, modern and contemporary textiles, plastic materials employed in design objects and in electronic devices). Application of LC to the characterisation of ageing/degradation products of (bioactive) organic dyes, as a result of natural or artificial ageing, also induced by electrochemical methods (cooperation with Heyrovský Institute, Prague)
Ilaria Degano (+39 0502219255)
ilaria.degano@unipi.it
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GC-MS

Development of analytical methods based on analytical pyrolysi, gas chromatography and mass spectrometry (Py-GC-MS) for the analysis of organic materials
Francesca Modugno (+39 0502219303)
francesca.modugno@unipi.it
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Bioactive compounds

Stereoselective synthesis of bio-active substances, also labelled with stable isotopes, belonging to the oxylipin and 3-amino-2-oxindole classes
Alessandro Mandoli (+39 0502219280)
alessandro.mandoli@unipi.it
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Heterometallic complexes

Synthesis and characterization of heterometallic complexes containing lanthanides and d transition metals, for applications in material chemistry and/or bioinorganics
Simona Samaritani (+39 0502219261)
simona.samaritani@unipi.it
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Microplastics

Methodologies for quantifying microplastics, impact assessment in marine and lake ecosystems, environmental remediation strategies, study of environmental degradation processes and of interaction with living organisms. New unfluorinated products for the hydrophobic and oleophobic surface modification of paper suitable for use as packaging materials and for disposable items as a replacement for plastic materials
Valter Castelvetro (+39 0502219256)
valter.castelvetro@unipi.it
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Polymers

Development of biocompatible and bioactive polymeric materials for biological tissue growth/regeneration and controlled drug release. Additive Manufacturing (3D Printing) and electrospinning of polymers and polymeric matrix composites
Dario Puppi (+39 0502219333)
dario.puppi@unipi.it
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Sustainability

PRA_2022_58 (2022-2024): The project aims at developing and optimising new applications of microwave (MW) irradiation for the treatment of complex samples, exploiting the specificity of MW heating mechanism, which allows a high reaction efficiency while reducing processing time. The project exploiting MW heating to develop and optimise different protocols to treat extremely complex matrices, for the extraction, hydrolysis, and recovery of specific analytes or high value products. In particular, we will treat matrices such as soil and water samples for the analysis of persistent organic pollutants, contaminants of emerging concern (CECs), microplastics and microfibers; biopolymers for the detection of amino acids, monosaccharides and fatty acids; plant biomass for the extraction of lignin and high value products, and poultry feathers for the recovery of keratin
Jeannette J. Lucejko (+39 0502219303)
jeannette.lucejko@unipi.it
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SSNMR

Application of Solid state NMR techniques to study the structural and dynamic properties of pharmaceuticals. Application of Solid state NMR techniques to study the structural and dynamic properties of materials for energy (e.g. photovoltaics) and environment
Marco Geppi (+39 0502219289)
marco.geppi@unipi.it
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Unimere micelles

Synthesis via controlled polymerization of amphiphilic random copolymers and study of their self-assembling behaviour in water for potential application in drug delivery and catalysis (PRIN 2022)
Elisa Martinelli (+39 0502219354)
elisa.martinelli@unipi.it
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Computational chemistry

Computational chemistry. Electronic correlation. Inter-molecular forces. Quantum Monte Carlo. DMRG. Methodological developments
Claudio Amovilli (+39 0502219399)
claudio.amovilli@unipi.it
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Biocatalysis

Enantioselective biotransformations for the synthesis of fine chemicals. Immobilization of enzymes for in batch and continuous flow reactions
Antonella Petri (+39 0502219279)
antonella.petri@unipi.it
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Prevention

Synthesis of non-peptidic small molecules for the prevention of neurodegenerative diseases
Rosarita D'Orsi (+39 0502219266)
rosarita.dorsi@gmail.com
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Algorithms

Development of fast algorithms and numerical techniques to computer molecular properties with multiscale methods. Software development within the Gaussian and CFOUR codes for the simulation of molecular properties and processes
Filippo Lipparini (+39 0502219269)
filippo.lipparini@unipi.it
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Metallic complexes

Synthesis of metal complexes for pharmacological and catalytic applications and their speciation in aqueous solution via IR, NMR and UV-Vis
Lorenzo Biancalana (+39 0502219223)
lorenzo.biancalana@unipi.it
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Carbonylative reactions

The research is focused on organometallic chemistry directed towards organic synthesis and in particular on carbonylative cross coupling reactions applied to the synthesis of carbonylated heterocyclic compounds and their use in solar cells devices and optoelectronics. Carbon monoxide moiety can be introduced as CO gas or by means of surrogates based on simple organic molecules such as HCOOH, CHCl3, oxalyl chloride, CO2 and metal carbonyls
Laura Antonella Aronica (+39 0502219274)
laura.antonella.aronica@unipi.it
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Organic synthesis

Development of new protocols for the synthesis of heterocyclic compounds via transition metals-promoted reactions; preparation of organic fluorophores for colourless luminescent solar concentrator (LSC) devices; synthesis and chiroptical characterization of chiral organic π-conjugated materials with outstanding chiroptical features; development of green and sustainable strategies in Palladium-catalyzed coupling reactions
Gianluigi Albano (+39 0502219277)
gianluigi.albano@unipi.it
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Antibiovegetative coatings

Photopolymerized films as protective coatings for marine antifouling and wood applications (funded by Maflon SpA)
Elisa Martinelli (+39 0502219354)
elisa.martinelli@unipi.it
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Biomass

Development of analytical tools mainly based on pyrolysis and mass spectrometry (Py-GC/MS, EGA-MS) to characterise lignocellulosic biomass and to study its reactivity under pyrolysis and co-pyrolysis conditions
Erika Ribechini (+39 0502219305)
erika.ribechini@unipi.it
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Green Hydrogen

Design, preparation and characterization of anion-exchange membrane and ionomers for water electrolysis for water electrolysis and green hydrogen production (funded by Enapter srl, PNRR PE2)
Elisa Martinelli (+39 0502219354)
elisa.martinelli@unipi.it
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Polymers

Synthesis and characterization of polyesters and co-polyesters from bio-based monomers for specific purpose
Grazia Totaro (+39 0502219319)
grazia.totaro@unipi.it
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Bio-based materials

Preparation and functionalization of crystalline nanocellulose. Processes to isolate nanocellulose (nanocrystals or nanofibers) from biomass. For the preparation of nanocellulose, enzymatic or acid hydrolysis of the starting cellulose pulps are preferred. Application of nanocellulose in various fields of materials science, in particular in paper consolidation and in the field of materials for photonics and electronics. Extraction and characterization of lignin materials and their application in optoelectronics and materials science
Alessandra Operamolla (+39 0502219342)
alessandra.operamolla@unipi.it
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Batteries

Design, preparation and characterization of innovative polymeric membranes for redox flow batteries (funded by GES srl)
Elisa Martinelli (+39 0502219354)
elisa.martinelli@unipi.it
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Pharmaceutical products

Consulting activity and scientific support to the industrial production of active pharmaceutical ingredients (API)
Alessandro Mandoli (+39 0502219282)
alessandro.mandoli@unipi.it
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Computational chemistry

Software development for the simulation of molecular properties and processes. Development of computational models for the simulation of light-activated processes in photoresponsive proteins. Computational modeling of energy and charge transfer processes in excitonic systems
Benedetta Mennucci (+39 05022192903)
benedetta.mennucci@unipi.it
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Nanomaterials

Nanocomposite semi-transparent films based on poly(dimethyl siloxane) as sunscreen filters with total UVA and UVB absorption, for skin application that are easily removable for single-use applications, to be used as protective devices for people suffering from genetic pathologies that cause hypersensitivity to solar radiation
Valter Castelvetro (+39 0502219256)
valter.castelvetro@unipi.it
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Metallic compounds

Inorganic and organometallic synthesis, including under inert atmosphere. Anhydrification and purification of solids. Solid state and solution characterization (analytical techniques; IR, NMR and UV spectroscopy). Applications in catalysis and medicine
Fabio Marchetti (+39 0502219245)
fabio.marchetti@unipi.it
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Other R&D organizations

Chema S.r.l.
UNIPI Spin-off: it proposes innovative solutions in Italy and abroad in the fields of applied research, technology transfer and specialist advice in the chemical, environmental and chemical industries.
Contacts: Valentina Domenici (+39 3772990144) - info@chemasrl.it
Web site: http://www.chemasrl.it
Metitech S.r.l.
Metitech wants to bring innovative solutions to the market for the monitoring of chemical parameters, through the development of sensors and the design of low-cost, portable, easy to use and possibly connected devices for remote data transfer. Metitech intends to respond to the concrete needs of its customers by providing devices that exploit combinations of innovative technologies and materials capable of combining the quality of chemical parameter measurements with ease of use, durability of the materials and the possibility of integrating and digitizing the information obtained
Contacts: Andrea Bonini (+39 3294052046) - andrea.bonini@metitech.net
Spin-PET S.r.l.
Spin-off UNIPI: it is an innovative company born from university research. As a spinoff of the University of Pisa, maintaining its own characteristics of originality, uniqueness and scientific/technological solidity, it carries out activities in the field of new polymer materials
Contacts: Francesco Ciardelli (+39 0887274832) - ciardelli@spinpet.it
Web site: http://www.spinpet.it/wp-site/it/

Collaborations with companies

  • AIMagn
  • AMBIENTE LAB S.R.L.
  • AOUP
  • BRUKER ITALIA S.r.l
  • CROMOLOGY
  • GR3N Italia
  • I&S Srl
  • INEOS
  • INOVYN
  • Labservice
  • Lucart SpA
  • MILESTONE Srl
  • Pangaia GradoZero srl
  • PIRELLI TYRE S.p.A
  • RINASCENZA TOSCANA
  • SIMS SRL
  • TCA Spa
  • Tecnocreo srl
  • TRE ZETA GROUP SRL

Pubblicazioni

  • F.Nardelli, F.Martini, E.Carignani, E.Rossi, S.Borsacchi, M.Cettolin, A.Susanna, M.Arimondi, L.Giannini, M.Geppi, and L.Calucci (2021). Glassy and Polymer Dynamics of Elastomers by 1H‐Field-Cycling NMR Relaxometry: Effects of Fillers, J. Phys. Chem. B, 125, 4546. doi: 10.1021/acs.jpcb.1c00885.
  • M.Meucci, S.Haveriku, M.Badalassi, C.Cardelli, G.Ruggeri, A.Pucci (2022). Effect of Polyolefin Elastomers’ Characteristics and Natural Magnesium Hydroxide Content on the Properties of Halogen-Free Flame-Retardant Polyolefin Composites, Micro, 2, 164. doi: 10.3390/micro2010011.
  • P.Minei, M.Lessi, L.Contiero, S.Borsacchi, F.Martini, G.Ruggeri, M.Geppi, F.Bellina, A.Pucci (2020) Boosting the NIR reflective properties of perylene organic coatings with T thermoplastic hollow microspheres: Optical and structural properties by a multi-technique approach, Solar Energy, 198, 689. doi: 10.1016/j.solener.2020.02.017.
  • G Pecorini, S Braccini, G Parrini, F Chiellini, D Puppi (2022). Additive Manufacturing of Poly(3-hydroxybutyrate-co-3-hy-droxyvalerate)/Poly(D,L-lactide-co-glycolide) Biphasic Scaffolds for Bone Tissue Regeneration. International Journal of Molecular Sciences, 23(7), 3895. doi: 10.3390/ijms2307389
  • D Puppi, A Pirosa, G Lupi, PA Erba, G Giachi, F Chiellini (2017). Design and fabrication of novel polymeric biodegradable stents for small caliber blood vessels by computer-aided wet-spinning. Biomedical Materials 12 (3): Article number 035011. doi: 10.1088/1748-605X/aa6a28

More info

Series of lectures entitled "The chemist in the modern society" - https://www.dcci.unipi.it/1030-chimico-societa-moderna-2022.html

PhD programs involving industries - https://dscm.dcci.unipi.it